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[(wer)5.8(e)-613.1(to)-615.9(b)12.8(e)-623.8(s)5.2(u)-1.2(c)12.8(c)-4.7(es)5.2(sf)12.8(u)-8(l)2.9(,)-609.8(t)-.3(he)-613.1(impa)12.8(ct)-613.6(could)-609.8(b)2.1(e)-613.1(s)-1.2(u)5.1(b)2.1(st)12.8(antia)12.8(l)]TJ
0 -1.2203 TD
.0112 Tc
[(i)-5(n)-447.4(both)-453.8(improving)-448.5(p)-2.8(a)11.2(t)-7.8(ient)-450.8(o)-4.2(u)3.5(tc)11.2(o)-9.8(m)1(e)11.2(s)-457.9(and)-453.4(r)4.2(educ)11.2(i)-10.6(n)1.5(g)-448.5(h)1.5(ealt)11.2(h)]TJ
0 -1.2266 TD
.0095 Tc
[(care)-344.5(costs.)]TJ
/F1 1 Tf
0 -3.054 TD
0 Tc
[(Stem)-339.8(Cells)-334.9(and)-331.9(Aging:)-335.2(SENS)-338(Foundation-Sponsored)]TJ
0 -1.2203 TD
(Session)Tj
/F4 1 Tf
1.1128 -1.8336 TD
[(Stem)-590.8(cell)-581.6(therapies)-591.8(and)-581.3(regenerative)-594.8(medicine)-585.5(will)-587.6(be)]TJ
-1.1128 -1.2266 TD
[(important)-414.4(for)-402.3(overcoming)-413.4(age-related)-409.7(deterioration.)-409.3(A)-406.1(spe-)]TJ
0 -1.2203 TD
[(cial)-619.2(conference)-616(session)-620.5(addressed)-618.6(advances)-613.7(in)-613.9(this)-615.7(area,)]TJ
T*
[(Unleashing)-523.3(Regenerative)-516.1(Medicine)-517.2(to)-515.4(Extend)-511.4(the)-515.9(Healthy)]TJ
T*
[(Lifespan:)-432.7(Technological)-426.7(Issues)-424.6(and)-429.5(Commercial,)-424.8(sponsored)]TJ
0 -1.2266 TD
[(by)-337.6(the)-332.5(SENS)-335.1(Foundation)-340.8(\(www.SENS.org\).)]TJ
1.1128 -1.2203 TD
[(M)-11.4(i)-9.9(c)-11.9(h)-9.7(a)-12.2(e)0(l)-262.7(W)0(e)-17.9(s)-14(t,)-262.6(CE)-15.8(O)-256(o)-9.1(f)-253.4(B)-9.3(i)-9.9(o)-9.1(T)-9.3(i)-9.9(m)-10.2(e)-252.8(\()-13.1(A)-7.7(l)-9.9(a)-12.2(m)-10.2(e)-12.5(d)-9.3(a)-12.2(,)-249.5(C)0(A)-20.5(\))-13.1(,)-249.5(d)-9.3(i)-9.9(s)-14(cu)-19.6(s)-7.6(s)-14(ed)]TJ
-1.1128 -1.2203 TD
.0106 Tc
[(the)-299.1(c)-1.3(ompanys)-300.5(diverse)-299.1(s)3(te)10.6(m)-303(c)-1.3(ell-)10.6(b)-6.9(a)-1.6(sed)-295.9(t)-2.5(e)10.6(c)-7.6(hno)-4.8(logy)-291(plat)10.6(f)-9.3(o)1.5(rm)]TJ
0 -1.2266 TD
0 Tc
[(w)-14.3(i)-9.9(t)-13.1(h)-597.7(s)-7.6(i)-16.2(x)-596.5(h)-9.7(u)-14(m)-10.2(an)-609.9(e)-12.5(m)-10.2(br)-17.8(y)-10.7(o)-9.1(n)-9.7(i)-9.9(c)-600(s)-14(te)-19.3(m)-598.2(c)-11.9(e)-12.5(l)-9.9(l)-597.9(\()-13.1(h)-9.7(E)-9.3(S)-11.1(C)-12.8(\))-601.1(l)-9.9(i)-9.9(n)-9.7(e)-12.6(s)-7.6(.)-603.6(T)-9.3(h)-9.7(e)]TJ
0 -1.2203 TD
.0122 Tc
[(hESC)12.2(s)-311.8(h)2.5(av)5.1(e)-303.8(b)1.5(een)-301(us)4.6(ed)-300.6(to)-300.4(diffe)12.2(r)-7.4(e)-.3(nt)12.2(iate)-303.8(2)12.2(0)-5.8(0)-303.5(d)2.9(owns)4.6(tr)5.2(eam)-301.5(c).3(e)12.2(l)-10.2(l)]TJ
T*
0 Tc
[(t)-13.1(y)-10.7(p)-7.7(e)-12.5(s)-387(s)-7.6(u)-14(c)-11.9(h)-382.8(a)0(s)-392.8(k)-10.7(i)-9.8(d)-9.3(n)-9.7(e)-12.5(y)-10.7(,)-382.3(s)-14(m)-10.2(o)-9.1(o)-9.1(t)-13.1(h)-382.8(m)-10.2(u)-7.7(s)-14(c)-11.9(l)-9.9(e,)-394.8(an)-21.9(d)-382.4(s)-7.6(k)-10.7(e)-12.5(l)-9.9(e)-12.5(ta)-19(l)-382.9(m)-10.2(u)-14(s)-7.6(c)-11.9(l)-9.9(e)]TJ
0 -1.2266 TD
.0111 Tc
[(cells.)-345.9(E)1.8(a)11.1(r)-8.1(ly)-347.4(in)-346.4(the)-349.2(p)3.4(rocess,)-345.9(c)-.8(e)11.1(l)-5(ls)-350.6(are)-349.2(e)-1.4(xpo)-4.3(s)3.5(ed)-346(to)-345.7(gro)-4.3(w)3.2(th)-346.4(fa)11.1(c)-6.7(-)]TJ
0 -1.2203 TD
[(tors)-356.8(t)11.2(o)-365.1(fa)11.2(c)-6.6(ilitat)11.2(e)-362.2(d)1.9(iffe)11.2(r)-8.4(e)-1.3(nt)11.2(i)-11.8(a)11.2(t)-7.8(i)1.3(on)-358.9(spe)11.2(c)-6.9(icity,)-352.1(f)-1.9(or)-356.2(exam)11.2(p)-6.7(l)1.3(e,)-352.1(os-)]TJ
T*
.0106 Tc
[(teogenic)-570.4(and)-574.1(c)-1.3(hon)-5.4(d)1.3(rogenic)-576.7(\()10.6(c)-8.1(a)-1.6(rtilage)10.6(-)-8.7(g)-.1(ene)10.6(r)-9(at)10.6(i)-6.1(n).9(g\))-577.9(growt)10.6(h)]TJ
T*
.0111 Tc
[(fact)11.1(o)-4.8(r)-2.2(s.)-560.9(S)11.1(i)-3.6(mil)-5.1(a)11.1(r)-8.1(l)1.2(y,)-554.6(hESCs)-552.9(w)3.2(ere)-551.5(d)1.8(iffe)11.1(r)-8.5(e)-1.4(ntia)11.1(t)-7.9(e)-1.4(d)-554.6(i)1.2(nto)-554.4(r)4.1(etina)11.1(l)]TJ
0 -1.2266 TD
.0106 Tc
[(pigment)-540(e)-1.9(pithelium)-543.4(\()10.6(R)-6.7(P)-3.4(E\))-540(stem)-537.1(cells)]TJ
6.7246 0 0 5.9768 468.6802 488.6361 Tm
0 Tc
(2)Tj
8.9663 0 0 8.9663 477.014 484.6676 Tm
.0101 Tc
[(a)10.1(n)-5.4(d)-543(a)-2.1(pplie)10.1(d)-549.2(c)-1.8(om-)]TJ
-18.2859 -1.2203 TD
.0106 Tc
[(merc)10.6(i)-4.9(a)-1.6(lly)-512.3(in)-517.6(a)-513.7(t)10.6(r)-9.5(e)-1.9(a)10.6(t)-8.4(ment)-514.7(f)10.6(o)-11.6(r)-508.6(m).4(acular)-514.9(de)10.6(g)-6.4(e)-1.9(neration.)]TJ
6.7246 0 0 5.9768 528.1511 477.6943 Tm
0 Tc
(3)Tj
8.9663 0 0 8.9663 536.2581 473.7259 Tm
.0094 Tc
(Bio-)Tj
-24.8933 -1.2203 TD
.0107 Tc
[(T)-5(i).8(me)10.7()-10.1(s)-863.2(subsidiary)-860(ReCyt)10.7(e)-874.9(Therapeut)10.7(i)-5.9(cs)-863.2(is)-869.5(spe)10.7(c)-7.5(ically)]TJ
0 -1.2266 TD
.018 Tc
[(f)4.9(o)8.9(c)6.1(u)4(s)10.4(e)5.5(d)-294.8(o)8.9(n)-295.2(t)4.9(h)8.3(e)5.5(r)11(a)5.8(p)10.3(i)8.2(e)5.5(s)-293.1(t)4.9(o)-294.6(r)4.7(e)18(ve)18(rs)10.4(e)-298(t)4.9(h)8.3(e)-291.7(de)18(ve)18(lop)10.3(m)7.8(e)5.5(n)8.3(t)4.9(a)18(l)-301.2(a)5.8(g)7.3(i)8.1(n)8.3(g)-296.2(o)8.9(f)]TJ
0 -1.2203 TD
.0109 Tc
[(h)-5.1(u)3.2(man)-378.2(c)10.9(e)-7.2(lls,)-371.4(u)-3.1(sin)-5.1(g)-372.9(hESC-de)10.9(r)-8.7(ive)10.9(d)-384(therapies)-376.1(f)-2.2(or)-375.5(age-)10.9(r)-9.2(e)10.9(l)-5.2(a)-1.3(te)10.9(d)]TJ
T*
.0111 Tc
[(vascular)-280.5(and)-282.7(b).4(lood)-282.8(disorder)4.1(s,)-276.3(such)-283.1(as)-281.1(coronar)4.1(y)-284.2(disease)-286(a)11.1(nd)]TJ
0 -1.2266 TD
.0107 Tc
[(h)-5.3(e)10.7(a)-7.7(r)-2.6(t)-432.4(f)10.7(a)-8.2(ilure.)]TJ
6.7246 0 0 5.9768 365.9527 422.929 Tm
0 Tc
(4)Tj
8.9663 0 0 8.9663 373.2661 418.9038 Tm
[(O)-9.4(t)-13.1(h)-9.7(e)-12.5(r)-443.3(r)-13.3(es)-20.2(ea)-18.4(r)-13.3(c)0(h)-451.6(i)-9.9(s)-443.9(i)-9.9(n)-9.7(v)-13.4(es)-20.2(t)-13.1(i)-9.9(g)-10.7(a)0(t)-18.9(i)-9.9(n)-9.7(g)-440.7(h)-16(y)0(a)-16.6(l)-9.9(u)-14(r)-7(o)-9.1(n)-16(at)-18.9(e)]TJ
-6.7149 -1.2203 TD
[(r)-13.4(e)-12.5(s)-7.6(t)-13.1(o)-9.1(r)-13.3(at)-19(i)-9.9(o)-9.1(n)-521.9(t)-13.1(h)-9.7(r)-7(o)-9.1(u)-14(g)-10.7(h)-521.9(s)-7.6(t)-13.1(em)-16.4(-)-13.1(c)-11.9(el)-16.1(l)-522(g)-10.7(e)-12.5(n)-9.7(e)-12.5(r)-7(a)-12.2(t)0(e)-19.3(d)-521.5(ex)-21(tr)-20.1(a)-12.2(c)0(e)-18.1(l)-9.9(l)-9.9(u)-14(l)-9.9(a)0(r)-525(m)-10.2(a)-12.2(-)]TJ
T*
[(t)-13.1(r)-13.3(i)-9.9(c)0(e)-18.2(s)-14(,)-578.3(a)-12.2(n)-9.7(d)-584.7(r)-7(e)-12.5(s)-7.6(e)-12.5(t)-13.1(t)0(i)-16.7(n)-16(g)-579.8(t)-13.1(el)-16.1(o)-9.1(m)-10.2(e)-12.5(r)-13.3(e)-581.6(l)-9.9(e)-12.5(n)-9.7(g)-10.7(t)0(h)-591.9(b)-10.7(ac)-17.8(k)-586.1(t)0(o)-591.3(b)-10.7(ef)-19.3(o)-9.1(r)-13.3(e)-581.6(t)-13.1(h)-9.7(e)]TJ
0 -1.2266 TD
.0108 Tc
[(Hayick)-284.5(limit)-286.8(through)-289.8(i).9(nduce)10.8(d)-295.6(pluripotent)-286.8(s)3.2(tem)-283.9(c)-1.1(ell)-283.6(\()-2.3(iPSC\))]TJ
0 -1.2203 TD
.0105 Tc
(reprogramming.)Tj
6.7246 0 0 5.9768 379.0487 379.0487 Tm
0 Tc
(5)Tj
8.9663 0 0 8.9663 323.0361 364.1385 Tm
.0113 Tc
[(Xianmin)-580.1(Z).7(e)11.3(n)-4.6(g,)-579.6(a)-576.2(r)4.3(esear)4.3(c)-.6(her)-577.4(a)11.3(t)-583(t)-1.8(he)-576.6(Buck)-574.8(Inst)11.3(itut)11.3(e)-583.4(f)-1.8(or)]TJ
-1.1128 -1.2203 TD
0 Tc
[(A)-14(g)-10.7(i)-9.9(n)-9.7(g)-440.7(R)-10.5(es)-20.2(e)-12.5(a)0(r)-19.2(c)-11.9(h)-439.7(\()0(N)-19.4(o)-9.1(v)-13.4(a)0(t)-18.9(o)-9.1(,)-439.2(C)-12.8(A)-7.7(\))-13.1(,)-439.2(p)-7.7(r)-13.3(e)-12.5(s)-7.6(e)-12.5(n)-9.7(t)-13.1(ed)-445.5(a)-12.2(d)-9.3(v)-7.1(a)-12.2(n)-9.7(c)-11.9(e)-12.5(s)-437.6(i)-9.9(n)-439.7(a)-12.2(d)-9.3(-)]TJ
0 -1.2266 TD
.0118 Tc
[(dr)4.8(es)4.2(sing)-454.2(Par)4.8(k)1.1(inson)-459.5(d)2.5(is)4.2(eas)4.2(e)-.7(.)-459(T)2.5(he)-456(cu)4.1(rr)4.8(ent)-462.9(t)11.8(r)-8.3(e)11.8(atme)11.8(n)-10.5(t)11.8(s)-8.9(,)-452.7(levo-)]TJ
0 -1.2203 TD
.01 Tc
[(d)-5.7(o).9(pa,)-353.3(d)-5.6(opamine)-356.6(a)-2.2(gonist)10(s)-10.8(,)-353.3(mono)-5.4(a)10(m)-6(in)-6(e)-356.6(o).9(xidase)-356.6(B)-359.7(\()-85.3(MAO-B\))]TJ
T*
.0111 Tc
[(inhibitor)4.1(s)-2.9(,)-345.9(a)-1.1(nd)-346(deep)-344.3(bra)11.1(i)-4.6(n)-352.7(s)3.5(timu)3.4(lation,)-352.2(a)11.1(r)-8.1(e)-349.2(not)-349.8(p)3.4(ar)4.1(ticu)3.4(larly)]TJ
0 -1.2266 TD
.5755 Tc
[(e)563(f)562.4(f)575.5(e)556.2(c)563.6(t)562.4(i)565.6(v)568.4(ea)563.3(n)565.8(d)-2.9(d)566.2(o)3.7(n)559.5(o)566.4(tc)563.6(u)567.8(r)562.2(et)575.5(h)552.7(e).2(d)566.2(i)565.6(s)567.9(e)563(a)563.3(s)567.9(e)563(.)3.5(C)562.7(e)563(l)565.6(l)2.9(r)562.2(e)575.5(p)555.3(l)565.6(a)563.3(c)575.5(e)557.3(m)565.3(e)562.9(n)565.8(t)]TJ
0 -1.2203 TD
.0109 Tc
[(thera)10.9(p)-8.9(ie)10.9(s)-407.6(m).7(ight)-400.6(be)-400(a)-399.6(s)-3.1(olut)10.9(ion)-403.5(f)-2.2(or)-400.8(comba)10.9(t)-8.1(ting)-398.2(the)-400(d)1.6(ea)10.9(t)-8(h)-403.5(of)]TJ
T*
.0144 Tc
[(ni)4.5(g)3.7(r)7.4(al)-570.8(d)5.1(o)5.3(pa)14.4(mi)4.5(n)4.7(e)1.9(rg)14.4(ic)-566.6(n)4.7(e)1.9(ur)7.4(o)5.3(n)4.7(s)-574.9(t)14.4(h)-8.4(a)14.4(t)-579.9(o)5.3(ccu)6.7(rs)-568.6(as)-568.6(th)4.7(e)-567.2(d)-1.2(i)4.5(s)6.8(ea)14.4(se)]TJ
0 -1.2266 TD
.0105 Tc
[(pro)-4.9(g)-.2(resse)10.5(s)-9.7(.)-416.1(C)10.5(l)-5.8(i).6(n)-5.5(i).6(c)10.5(a)-7.3(lly)-417.6(compliant)-419.9(ste)10.5(m)-423.2(cell)-416.7(lines)-414.4(ca)10.5(p)-9.3(a)10.5(b)-6.1(l).6(e)-419.4(o)1.4(f)]TJ
0 -1.2203 TD
0 Tc
[(d)-15.7(i)-9.9(ff)-19.9(e)-12.5(r)-7(e)-12.5(n)-9.7(t)-13.1(i)-9.9(at)-19(i)-9.9(n)-9.7(g)-516.6(i)-9.9(n)-16(t)0(o)-528(m)-10.2(i)-9.9(d)-9.3(b)-10.7(r)-7(a)-12.1(i)-9.9(n)-515.5(n)-16(eu)-20.2(r)-7(o)-15.4(n)-9.7(s)-519.8(w)-8(e)-12.5(r)-7(e)-518.4(s)-14(e)0(l)-16.1(e)-12.5(c)-11.9(t)0(e)-19.3(d)-9.3(,)-521.4(a)0(n)-15.5(d)]TJ
T*
.0114 Tc
[(iPSCs)-242.8(w)3.5(er)4.4(e)-241.4(u)-2.6(sed)-244.5(t)11.4(o)-251.1(g).7(ener)4.4(ate)-241.4(c)-.5(ommit)11.4(t)-8.5(ed)-244.5(ne)11.4(u)-8.8(r)4.4(ona)11.4(l)-250.9(st)11.4(e)-7.9(m)-239.1(cells,)]TJ
T*
.012 Tc
[(which)-427.7(w)-2.3(er)5(e)-430.5(t)-1.1(hen)-427.7(f)-1.1(ur)5(ther)-431.3(dif)12(f)-7.9(er)5(entia)12(t)-6.9(ed)-427.3(int)12(o)-440.2(dopa)12(mine)12(r)-7.6(g)1.3(ic)]TJ
0 -1.2266 TD
.0172 Tc
[(ne)17.2(ur)10.2(on)7.5(s)9.6(.)]TJ
6.7246 0 0 5.9768 347.8676 236.5795 Tm
0 Tc
(6)Tj
8.9663 0 0 8.9663 356.1448 232.611 Tm
.0105 Tc
[(The)-539.5(s)2.9(tabilit)10.5(y)-544.5(a)-1.7(nd)-536.3(delit)10.5(y)-544.5(o)1.4(f)-540.1(t)10.5(h)-12.3(e)-533.2(dopa)10.5(m)-5.5(i).6(n)-5.5(e)10.5(r)-9.1(g)-.2(ic)]TJ
-4.8054 -1.2203 TD
0 Tc
[(n)-16(e)0(u)-20.2(r)-7(o)-15.4(n)-9.7(s)-304.8(h)-9.7(a)-12.2(s)-311.1(be)-17(e)-12.5(n)-306.9(c)-11.9(o)-9.1(n)-9.7()-9.3(r)-13.3(m)-10.2(ed)-319(an)-15.5(d)-306.5(t)-13.1(h)-9.7(e)-309.7(n)-9.7(e)-12.5(x)-8.5(t)-310.3(s)-7.6(t)-13.1(e)-12.5(p)-304.9(i)-9.8(s)-311.1(s)-7.6(c)-11.9(al)-22(i)-9.8(n)-9.7(g)-307.9(u)-7.7(p)]TJ
T*
.0106 Tc
[(pro)-4.8(d)1.3(uction)-277.3(f)10.6(o)-5.3(r)-274.6(c)-1.3(linical)-271.1(trials.)-270.5(T)1.3(hi)-5.6(s)-268.9(l).7(o)-4.8(o)1.5(ks)-275.2(f)10.6(e)-8.7(asible)-273.8(bec)10.6(a)-7.2(use)-273.8(life)]TJ
0 -1.2267 TD
.0121 Tc
[(scie)12.1(n)-10.2(c)12.1(es)-387.6(pr)5.1(odu)4.4(c).2(t)-393(m)12.1(anuf)12.1(act)12.1(u)-8.7(r)5.1(e)-.4(r)-393.3(L)2.8(onza)-385.8(is)-393.9(de)12.1(v)-7.5(e)-.4(lop)4.4(i)-4.1(ng)-384.3(dop)4.4(a)-.1(-)]TJ
0 -1.2203 TD
.0117 Tc
[(mine)11.7(r)-7.9(g)1(ic)-449.2(neur)4.7(on)-453.3(pr)4.7(oduct)11.7(s)-458(wit)11.7(h)-460(thes)4.1(e)-456.1(m)11.7(ethods.)-452.8(A)-451.3(r)4.7(e)-.8(a)11.7(d)-9.8(ily)]TJ
T*
.0097 Tc
[(av)-3.7(a)9.7(i)-6(lable)-584.5(s)-4.3(up)-4.3(ply)-589.1(o).6(f)-585.1(i)-6.5(PSC)-3.1(-)9.7(d)-6.4(e)-2.8(ri)-6.5(ved)-587.7(d).4(opaminergic)-590.2(n)0(eur)-3.6(o).6(ns)]TJ
0 -1.2266 TD
.0111 Tc
[(could)-561(f)-2(a)11.1(c)-6.7(ilita)11.1(t)-7.9(e)-564.2(r)4.1(esearch)-561.3(i)1.2(n)-561.3(o)2(ther)-558.7(neurodegene)11.1(r)-8.5(at)11.1(i)-5.5(v)-2.3(e)-557.9(d)1.8(is-)]TJ
0 -1.2203 TD
0 Tc
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T*
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T*
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T*
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T*
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T*
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T*
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28.0042 74.5598 TD
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T*
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T*
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T*
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T*
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T*
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[(b)-10.7(a)0(c)-17.8(k)-358.5(t)-13.1(o)-356.9(a)-359.9(p)-14(l)-9.9(u)-7.7(r)-13.3(i)-9.9(p)-7.7(o)-9.1(t)-13.1(e)-12.5(n)-9.7(t)-360.9(s)-7.6(t)-13.1(a)-12.2(g)-10.7(e,)-369.5(w)-7.9(h)-9.7(e)-12.5(r)-7(e)-360.3(t)-13.1(h)-9.7(e)-12.5(y)-358.5(c)-11.9(an)-369.6(th)-22.8(en)-370(b)-10.7(e)-360.3(d)-9.3(i)-9.9(ff)-19.9(e)-12.5(r)-7(-)]TJ
T*
[(en)-22.3(ti)-16.7(a)-12.2(t)-13.1(ed)-496.1(i)-9.9(n)-9.7(t)-13.1(o)-483.3(a)-12.2(n)-9.7(y)-491.3(c)0(e)-18.2(l)-9.9(l)-490.4(t)0(y)-17.5(p)-14(e.)-496(A)-488.3(l)-9.9(an)-21.9(d)-9.3(m)-10.2(ar)-19.2(k)-485(p)-14(ap)-19.8(er)-493.8(w)-14.3(a)0(s)-494(p)-14(u)-7.7(b)-10.7(-)]TJ
0 -1.2266 TD
.0107 Tc
[(lish)-5.3(e)10.7(d)-333.6(i).8(n)-327.8(200)10.7(6)-7.3(,)]TJ
6.7246 0 0 5.9768 369.2408 455.8109 Tm
.0143 Tc
(18)Tj
8.9663 0 0 8.9663 379.1054 451.7857 Tm
0 Tc
[(w)-7.9(i)-9.9(t)-13.1(h)-338.5(o)-9.1(n)-9.7(g)-10.7(o)-9.1(i)-9.9(n)-16(g)-333.2(a)-12.2(d)-9.3(v)-13.4(an)-15.5(c)-11.9(e)-12.5(s)-336.4(f)-13.1(r)-7(o)-15.4(m)-332.7(t)-13.1(h)-9.7(e)-341.3(s)-7.6(a)-12.2(m)-10.2(e)-335(l)-9.8(a)-12.2(b)]TJ
-7.6128 -1.2203 TD
.0103 Tc
[(includin)-5.7(g)-417.8(t)-2.8(he)-419.6(recent)-420.1(dire)10.3(c)-7.8(t)-420.1(re)10.3(p)-9.9(r)3.3(o)-5.1(g)10.3(r)-7.5(a)-1.9(mm)10.3(i)-9.8(n).6(g)-417.8(o)1.2(f)-420.1(o)-5.1(ne)-419.6(mat)10.3(u)-10.5(re)]TJ
T*
.011 Tc
[(ce)11(l)-5.1(l)-675.4(lin)-5(e)11(a)-7.4(ge)-671.8(to)-674.6(another.)-674.8(Adult)-678.7(d)1.7(ermal)-675.4()1.7(brob)11(last)11(s)-686.3(w)3.1(ere)]TJ
0 -1.2266 TD
.0104 Tc
[(t)10.4(r)-9.7(ansforme)10.4(d)-327.6(i).5(nto)-314.8(f)-2.7(unc)10.4(t)-8.3(ion)-5.6(a)10.4(l)-327.8(n).7(eurons)-319.7(with)-321.8(a)-317.9(c)-1.5(ombina)10.4(t)-8.6(i).5(on)-321.8(of)]TJ
0 -1.2203 TD
0 Tc
[(a)-252.4(m)-10.2(i)-9.9(c)0(r)-19(o)-9.1(R)-10.6(N)-12.6(A)-254.3(\()0(m)-17(i)-9.9(R)-10.6(-)-13.1(12)-18(4)-12.2(\))-253.4(an)-15.5(d)-255.9(t)0(w)-21.1(o)-249.4(t)-13.1(r)-7(a)-12.2(n)-9.7(s)-14(c)0(r)-19(i)-9.9(p)-14(t)0(i)-16.7(o)-9.1(n)-256.3(f)-13.1(ac)-17.8(t)-13.1(o)-9.1(r)-7(s)-254.2(\()-95.3(M)-11.4(y)-10.7(t)0(1)-19(l)]TJ
T*
[(an)-21.9(d)-477.2(B)-9.3(r)-13.3(n)-9.7(2)-12.2(\))0(.)]TJ
6.7246 0 0 5.9768 354.5007 400.9889 Tm
.0143 Tc
(19)Tj
8.9663 0 0 8.9663 365.6692 397.0204 Tm
.0095 Tc
[(One)-470.9(o).4(f)-471.5(t)-3.6(he)-470.9(r)-3.8(st)-471.5(t)-3.6(e)-3(st)-3.6(s)-466(t)-3.6(hat)-471.5(s)1.9(cient)-3.6(i)-.4(st)-3.6(s)-472.3(c)9.5(o)-11.5(n)-.2(duct)]TJ
-6.1143 -1.2266 TD
.011 Tc
[(a)11(f)-8(te)11(r)-457.5(g).3(ener)4(ating)-448.7(i)1.1(PSCs)-451.9(is)-451.9(whethe)11(r)-457.5(t)-2.1(hey)-448.7(a)-1.2(r)4(e)-450.5(the)-450.5(f)-2.1(unctional)]TJ
0 -1.2203 TD
0 Tc
[(eq)-17(u)-14(i)-9.9(v)-7.1(a)-12.2(l)-9.9(e)-12.5(n)-9.7(t)-341.9(o)-15.4(f)-341.9(E)-9.3(S)-11.1(Cs)-20.4(.)]TJ
1.1128 -1.2203 TD
[(T)16(h)0(e)15.7(r)0(e)-342(a)0(r)18.8(e)-354(so)21.2(me)-345.2(pr)23.2(ob)18.1(le)15.5(m)15.1(a)0(t)19(i)0(c)-344.3(a)0(s)18.1(p)0(e)17.7(c)13.4(ts)-343.2(in)-342(wo)14.6(rk)20.2(in)18.4(g)-352.2(w)0(i)20.1(t)12.2(h)-351.2(b)0(o)18.1(t)0(h)]TJ
-1.1128 -1.2203 TD
[(ES)17.5(C)12.5(s)-311.1(an)16.1(d)-312.8(i)0(P)20.4(S)0(C)20.3(s)0(;)-307.7(f)12.2(or)-307(e)12.7(x)0(a)17.3(m)0(p)20(l)0(e)15.5(,)-312.7(in)18.4(c)13.4(o)0(m)18.6(p)0(l)20.4(e)0(t)18.6(e)-316(di)18.8(f)12.2(f)0(e)18.6(r)0(e)18.4(n)0(t)15.1(i)0(a)22.2(t)0(i)21.3(o)0(n)-309.7(m)0(a)21.9(y)]TJ
0 -1.2266 TD
[(le)21.9(ad)-407.2(to)-414.2(t)12.2(e)0(r)18.4(a)0(t)19(o)0(m)18.6(a)-416.8(\(t)18(um)20.1(or)15.5(\))-417.8(f)0(o)15.7(r)0(m)20.7(a)13.1(ti)15(on)-410.8(or)-408.1(t)12.2(h)0(e)-414.3(b)14.6(ui)14.1(l)15.4(d)0(u)14.6(p)-418.7(of)-407.9(ot)15.7(he)22(r)]TJ
0 -1.2203 TD
[(un)20.5(us)16.3(a)13.1(b)0(l)17.3(e)-354(ex)16.9(tr)17.8(a)-353.6(c)0(e)13.5(l)15.4(ls)14.1(.)-357(A)0(l)20.4(s)0(o)21.2(,)-357(it)-351.8(m)15.1(a)0(y)-351.7(b)14.6(e)-360.3(d)0(i)18.8(f)12.2(c)16.7(ul)20.4(t)-360.9(t)12.2(o)-356.9(i)0(d)18.8(e)0(n)15.7(t)12.2(if)21.3(y)-358.5(a)0(n)16.1(d)]TJ
T*
[(se)17.8(pa)24.4(ra)18.8(te)-253.3(f)12.2(u)0(l)20.4(l)0(y)-248.2(d)0(i)18.8(f)0(f)18(e)0(r)18.4(e)12.8(nt)15.1(ia)22.3(te)18.6(d)-262.2(c)13.4(el)15.5(ls)-245.1(in)-247.2(cu)18.3(lt)15(ur)23.2(e)-259.1(f)0(o)15.7(r)]TJ
/F8 1 Tf
20.1132 0 TD
[(in)-252.9(v)13.1(i)0(v)17.6(o)]TJ
/F4 1 Tf
3.0097 0 TD
-.0122 Tc
[(tr)-12.2(a)6.6(n)-12.2(s)8.4(f)-12.2(e)6.4(r)-12.2(.)]TJ
-23.1229 -1.2266 TD
0 Tc
[(Th)18.9(e)12.7(r)0(e)-291.5(a)13.1(re)-291.5(is)20.4(su)16.3(e)12.7(s)-298.5(re)18.4(la)22.2(te)18.6(d)-300.2(t)12.2(o)-299.9(i)0(P)20.4(S)0(C)-289.5(g)0(e)21(n)0(e)15.7(r)0(a)18.8(t)12.2(io)19(n,)-290.8(su)22.6(ch)-287.2(as)-291.7(pr)23.2(ob)18.1(le)15.5(m)15.1(s)]TJ
0 -1.2203 TD
[(wi)20.1(t)12.2(h)-566.1(th)15.1(e)-562.6(r)0(e)18.4(t)0(r)17.8(o)0(v)21.8(i)0(r)14.7(a)13.1(l)-566.3(d)0(e)16.1(l)15.4(iv)14.7(e)12.8(r)0(y)-555.2(m)0(e)15.2(t)12.2(ho)19.1(d)-565.7(a)0(n)16.1(d)-559.4(th)15.1(e)-562.6(t)0(r)17.8(a)0(n)16.1(s)0(c)18.4(r)0(i)21.1(p)0(t)17.1(i)0(o)19(n)]TJ
T*
[(f)12.2(a)0(c)20.2(t)0(o)15.7(r)0(s)17(.)-376(Ri)17.5(go)18.1(ro)21.8(us)-375.7(a)13.1(n)0(a)16.1(l)15.4(ys)19.6(is)-371.6(ha)16.1(s)-380.7(f)12.2(ou)14.8(nd)-366.8(th)15.1(a)13.1(t)-386.2(iP)20.4(S-)20(ge)21(ne)15.7(ra)18.8(t)12.2(e)0(d)-369.6(c)0(e)13.5(l)15.4(ls)]TJ
0 -1.2266 TD
[(ma)21.9(y)-326.9(n)0(o)19.1(t)-322.9(be)-320.5(f)12.2(u)0(n)20.5(c)0(t)19.2(i)0(o)19(n)0(a)16.1(l)0(l)18.2(y)-320.6(an)16.1(d)-325.5(m)0(o)18.6(l)0(e)21.9(c)0(u)18.3(l)0(a)22.2(r)0(l)14.7(y)-320.6(eq)14.7(ui)20.4(va)18.7(le)21.9(nt)-320(t)12.2(o)-325.2(ES)17.5(C)12.5(s)0(,)]TJ
0 -1.2203 TD
[(b)14.5(e)0(c)13.5(a)13.1(us)16.3(e)-417.2(a)0(b)15(e)12.7(rr)17.6(a)13.1(n)0(t)-414.8(g)0(e)21(n)0(e)-414.3(s)0(i)20.4(l)0(e)21.9(n)0(c)16.3(i)0(n)18.4(g)]TJ
6.7246 0 0 5.9768 436.9322 269.4614 Tm
-.0194 Tc
(20)Tj
8.9663 0 0 8.9663 447.3069 265.4929 Tm
0 Tc
[(an)16.1(d)-420.3(p)0(o)21.2(i)0(n)18.4(t)-424.1(mu)20(t)12.2(a)0(t)19(i)0(o)19(n)0(s)-415.7(m)15.1(ay)]TJ
-15.2192 -1.2203 TD
[(oc)23.2(cu)18.3(r.)-439.9(On)18.9(e)-448.8(s)0(t)17.2(u)0(d)20.9(y)-453.3(f)12.2(o)0(u)14.8(n)0(d)-436.3(t)0(h)15.1(a)13.1(t)-449.4(i)0(P)20.4(S)-453.7(re)18.4(pr)23.2(og)18.1(ra)18.8(mm)23.8(in)18.4(g)-453.3(i)0(n)-436.9(2)0(2)-441.6(c)13.4(el)15.5(l)]TJ
T*
[(li)18.2(ne)22(s)-412.3(u)0(s)22.6(i)0(n)18.4(g)-409.1(v)21.5(e)-410.9(d)0(i)18.8(f)12.2(fe)18.6(re)18.4(nt)-402.2(me)21.5(th)15.1(od)19.5(s)-406(r)0(e)18.4(s)0(u)16.3(l)0(t)21.3(e)0(d)-401.2(i)0(n)-398.9(a)13.1(n)-408.1(a)0(v)18.7(e)0(r)18.4(a)0(g)21.4(e)-410.9(of)]TJ
0 -1.2266 TD
[(v)21.5(e)-417.2(p)0(o)14.8(i)0(n)18.4(t)-417.8(m)15.1(u)0(t)17.1(a)0(t)19(i)0(o)19(n)0(s)-409.4(i)0(n)-411.6(t)12.2(he)-408(re)18.4(gi)17.3(on)19.1(s)-418.6(s)0(a)24.5(m)0(p)13.7(l)15.4(ed)16.1(.)]TJ
6.7246 0 0 5.9768 490.1101 236.5795 Tm
(21)Tj
8.9663 0 0 8.9663 500.4849 232.611 Tm
[(Ot)15.5(he)22(r)-418(r)0(e)18.4(c)0(e)19.8(n)0(t)]TJ
-21.1501 -1.2203 TD
[(wo)20.9(rk)-333.9(e)12.7(x)0(a)17.3(m)0(i)17.9(n)0(e)22(d)-344.4(t)12.2(h)0(e)-332.1(e)0(x)16.9(t)0(e)18.6(n)0(s)20.6(i)0(v)14.7(e)-341.3(re)18.4(g)14.6(u)0(l)14.1(a)13.1(to)15.7(ry)-327.6(pr)16.9(oc)16.9(e)12.7(s)0(s)-337.7(t)12.2(ha)16.1(t)-341.9(a)13.1(cc)20.4(om)18.6(-)]TJ
T*
[(pa)18.1(ni)24.7(es)-488.1(de)22.4(di)18.8(ff)18(er)18.4(en)15.7(t)12.2(i)0(a)22.3(t)0(i)15(o)0(n)-480.4(a)0(n)16.1(d)-489.9(re)18.4(di)18.8(f)12.2(f)0(e)18.6(r)0(e)18.4(n)0(t)15.1(i)0(a)22.2(t)0(i)15(o)0(n)19.1(,)-489.8(an)16.1(d)-489.9(h)0(o)19.1(w)-494.8(t)12.2(h)0(e)]TJ
0 -1.2267 TD
[(e)12.7(p)0(i)14.1(g)14.6(en)15.7(e)12.7(t)0(i)15(c)-321.8(la)22.3(nd)18.9(sc)18.4(ap)18.1(e)-322.4(m)0(a)15.6(y)-320.6(be)-314.1(re)18.4(se)17.8(t)-322.9(i)0(n)-316.7(i)0(P)20.4(S)0(C)20.3(s)-323.8(as)-317(so)21.2(me)-319.9(c)13.4(e)0(l)15.5(l)15.4(s)-330.1(u)0(p)22.6(-)]TJ
0 -1.2203 TD
[(re)18.4(g)14.6(u)0(l)14.1(a)13.1(te)-430.3(a)13.1(n)0(d)-430(d)16(ow)14.6(nr)21.2(eg)21(ul)14.1(a)13.1(t)0(e)-430.3(m)15.1(or)15.5(e)-436.2(q)0(u)19.5(i)0(c)22.5(k)0(l)17.3(y)-434.4(th)15.1(a)13.1(n)-439.7(ot)22(he)15.7(rs)-425.6(wh)20.3(en)]TJ
T*
[(t)12.2(r)0(a)18.8(n)0(s)20.6(c)0(r)19(i)0(p)14.1(t)12.2(io)19(n)-332.2(f)12.2(ac)13.9(t)12.2(o)0(r)21.8(s)-336.4(a)13.1(r)0(e)-323.1(a)13.1(pp)16.3(li)18.2(e)12.7(d)0(.)]TJ
6.7246 0 0 5.9768 437.9526 181.8141 Tm
(22)Tj
8.9663 0 0 8.9663 447.5904 177.8456 Tm
[(A)-330.2(b)0(e)21(t)0(t)18(e)0(r)-323.1(u)0(n)20.6(d)0(e)16.1(r)0(s)17(t)12.2(an)16.1(di)25.1(ng)-324(of)]TJ
-15.2509 -1.2266 TD
[(t)12.2(h)0(e)-325.8(m)0(e)21.5(c)0(h)16.3(a)13.1(ni)18.4(cs)-323.1(of)-325.7(re)24.7(pr)16.9(og)18.1(ra)18.8(mm)23.8(in)18.4(g)-333.2(t)12.2(o)-337.9(p)0(l)20.4(u)0(r)23.2(i)0(p)14.1(o)0(t)22(e)0(n)15.7(c)13.4(y)-333.2(m)0(i)17.9(g)14.6(ht)-326.3(he)22(lp)]TJ
0 -1.2203 TD
[(in)-228.2(t)12.2(h)0(e)-230.9(d)0(i)18.8(r)0(e)18.4(c)13.4(t)-240.7(r)0(e)18.4(p)0(r)23.2(o)0(g)18.1(r)0(a)18.8(m)0(m)17.5(i)15.4(ng)-229.1(of)-230.9(on)19.1(e)-240.2(l)15.4(in)18.4(ea)19.6(ge)-231.9(t)12.2(o)-236.7(an)16.1(ot)22(he)15.7(r)-234.6(w)0(i)20.1(t)0(h)15.1(o)0(u)21.2(t)]TJ
T*
[(ha)22.4(vi)14.7(ng)-311.3(t)12.2(o)-325.2(in)18.4(du)20.9(ce)-315.3(pl)20.4(ur)16.9(ip)20.4(ot)15.7(e)12.7(n)0(c)16.3(y)0(.)]TJ
1.1128 -1.2266 TD
[(O)15.9(t)0(h)15.1(e)12.7(r)-443.3(t)0(e)18.6(c)0(h)16.3(n)0(i)18.4(q)0(u)19.5(e)12.7(s)-443.9(f)0(o)15.7(r)-443.3(g)14.6(e)0(n)15.7(e)12.7(ra)18.8(ti)15(ng)-431.4(iP)20.4(SC)20.3(s)-443.9(a)0(r)18.8(e)-442.5(un)20.6(de)16.1(r)-443.3(i)0(n)18.4(v)0(e)18.3(s)0(t)23.5(i)0(-)]TJ
-1.1128 -1.2203 TD
[(g)14.5(a)0(t)19(i)0(o)19(n)0(,)-227.6(i)15.4(nc)16.3(lu)20.4(di)18.8(ng)-222.8(re)18.4(pl)20.4(ac)20.2(in)18.4(g)-232(t)12.2(he)-224.6(tr)17.8(an)16.1(sc)24.7(ri)14.7(pt)17.1(i)15.4(o)0(n)-227.5(f)12.2(ac)20.2(to)15.7(rs)-223.3(wi)20.1(t)12.2(h)-231(sm)20.1(al)15.9(l)]TJ
T*
[(mo)18.6(le)21.9(cu)18.3(le)21.9(s)-450.2(a)13.1(nd)-436.3(so)21.2(me)-440.1(re)18.4(c)13.4(e)0(n)15.7(t)-443.1(pr)16.9(om)18.6(is)20.4(e)-442.5(i)0(n)-436.9(t)0(h)15.1(e)-442.5(ta)19(rg)20.2(et)18.6(ed)-439.2(ge)21(ne)15.7(t)12.2(i)0(c)]TJ
T*
[(e)12.7(n)0(g)17.5(i)0(n)18.4(e)12.7(er)18.4(in)18.4(g)-573.5(o)0(f)-559.7(h)0(u)14.2(m)15.1(an)-565.6(pl)20.4(ur)16.9(i)15.4(p)0(o)14.8(t)12.2(en)15.7(t)-569.5(c)0(e)19.8(l)0(l)18.2(s)0(.)-560.6(N)0(u)17.6(c)0(l)16.2(e)12.8(as)18.1(e)12.8(s)-576.7(\()12.2(D)0(N)17.6(A)0(-)]TJ
0 -1.2266 TD
[(c)13.4(l)0(e)15.5(a)13.1(vi)14.7(ng)-595.8(en)15.7(z)13.1(y)0(m)17(e)12.8(s\))-602.5(ha)22.4(ve)-601.3(sh)20.6(ow)14.6(n)-604.1(s)0(o)14.9(m)0(e)-598.1(s)0(u)22.6(c)0(c)14.1(e)12.7(ss)-603.3(in)-595(di)18.8(re)18.4(ct)19.2(ed)]TJ
0 -1.2203 TD
[(g)14.5(e)0(n)15.7(e)0(t)18.6(i)0(c)-382.2(p)0(r)16.9(o)0(g)24.4(r)0(a)18.8(m)0(m)17.5(i)0(n)18.4(g)14.6(,)-394.9(f)12.2(or)-382.8(so)14.9(m)15.1(e)-391.9(ti)15(m)15.1(e)-391.9(wi)20.1(th)-383.2(zi)15.9(nc)22.6(-)15.5(ng)17.5(e)12.7(r)-392.7(nu)20.5(cl)16.2(e)12.7(-)]TJ
T*
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